Browsing by Author "Bhowmick, Aditi"

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Physicochemical Properties Analysis of Marketed Amitriptyline Hcl Tablets Available in Bangladesh
(Pharmacologyonline, 2019-12-30) Bhowmick, Aditi; Saha, Tushar; Mondal, Shadhan Kumar; Sovon, Md. Shafiqul Islam; Khan, Amran; Masum, Zia Uddin; Hossain, Md. Sakhawat
The aim of the present investigation was to analyze different physicochemical parameters of marketed Amitriptyline HCI tablets (10mg) available in Bangladesh. Five brands were chosen randomly and purchased from Dhaka city Bangladesh. Diameter, thickness, hardness, friability and disintegration time were performed as per USP monograph and found satisfactory result. In vitro dissolution study was conducted by using apparatus 1 and in 0.1 N HCl media. Four of the five brands successfully met the compendia requirements after 45 minutes where as one brand failed to meet the official monograph. From the investigation it is recommended that pharmacovigilance should be adopted strongly so as to ensure the quality of the product.
Phytochemical Analysis and Antioxidant, Thrombolytic, Astringent, Pro-coagulant Properties Investigation of Tagetes Lucida
(Pharmacologyonline, 2019-12-30) Hossain, Md. Sakhawat; Nijhum, Nisarat; Mondal, Shadhan Kumar; Masum, Zia Uddin; Sovon, Md. Shafiqul Islam; Khan, Amran; Bhowmick, Aditi; Saha, Tushar
The aim of the present investigation was to evaluate the phytochemical and biological properties (antioxidant, thrombolytic, astringent and pro-coagulant) of Tagetes lucida. Freshly prepared crude extracts of Tagetes lucida were qualitatively tested for the presence of various chemical constituents including carbohydrates, alkaloids, flavonoids, glycosides, gums, steroids and saponins. These were identified by observing characteristic color changes using standard procedures. In phytochemical investigations, the presence of carbohydrates, alkaloids and flavonoids were identified but glycosides, gums, steroids and saponins were absent. The crude methanolic extract of Tageres lucida showed significant thrombolytic activity. The plant leaves extracts had anti-oxidant activity but not in a significant manner. Medical astringents are considered to stop or slow bleeding and to help wounds heal. The leaves of Tagetes lucida showed astringent properties. Procoagulant platelets are predominantly localized at thrombus surface. The leaves of Tagetes lucida showed pro-coagulant properties.
Possibilities of Medicinal Plants to Treat SARS-CoV-2
(Scopus, 2020) Johora, Umme Fatema Tuj; Hossain, Md. Sakhawat; Sultana, Sharifa; Nizhum, Nisarat; Bhowmick, Aditi; Roy, Arpita; Mondal, Shadhan Kumar; Saha, Tushar
The new Corona-virus, recently called the severe acute respiratory syndrome Coronavirus (SARS-CoV-2) appears for the first time in China and more precisely in Wuhan (December 2019). This infection can be deadly. Seniors, and individuals with other restorative conditions may be more helpless and ended up truly sick. Typically why inquire about into drugs to treat this contamination remains basic in a few investigate laboratories. Natural home grown cures have long been the most, in case not the as it were, cure within the verbal convention for treating sicknesses. Advanced pharmaceutical has known its victory much appreciated to conventional medication, the adequacy of which determines from therapeutic plants. The objective of this think about is to decide in case the components of common root have an anti-viral impact and which can anticipate people from disease by this coronavirus utilizing the foremost dependable strategy is atomic docking, which utilized to discover the interaction between considered atoms and the protein, in our case we based on the inhibitor of Coronavirus (nCoV-2019) primary protease. Chinese Pharmaceutical herbs might be a profitable pool for distinguishing active compounds for treating disease of 2019-nCoV. In this think about, we summarize several dynamic compounds, counting baicalin, Scutellarin, Hesperetin, Nicotianamine and glycyrrhizin that may have potential anti-2019-nCoV effects. We conduct atomic docking to anticipate their capacity for authoritative ACE2, which may anticipate the 2019-nCoV disease. We propose that these chosen compounds worth assist examination for avoiding 2019-nCoV
Prospects of 4d Printing in Pharmaceuticals
(Scopus, 2020) Roy, Arpita; Hossain, Md. Sakhawat; Bhowmick, Aditi; Nizhum, Nisarat; Mondal, Shadhan Kumar; Saha, Tushar
4D printing is a fledgling technology with enormous potential that may bring revolution to the future manufacturing industry along with pharmaceuticals. MIT's Self Assembly Lab and Stratasys education and R&D department first developed this concept jointly in 2013. 3D printing has already proved its competence and achieved wide acceptance after being invented in 1984. 4D printing is an up-gradation of 3D printing technology. 4D printing adopts time as the 4th dimension. It allows the fabrication of stimuli-responsive 3D structures that can independently change its morphology over time. External stimuli such as light, pH, magnetic field, moisture content, etc. can trigger the shape-changing event. 4D printing technology can be applied to develop site-specific, controlled release as well as a customized drug delivery system. Researchers are also optimistic about its application in the biomedical sector. This paper presents a comprehensive review of the basic mechanism of 4D printing technology and its possible future application and prospects in the pharmaceuticals and biomedical fields.