Browsing by Author "Bashar, Md. Abul"

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A review on the use of biosimilars in the treatment of rheumatoid arthrities
(BRAC University, 2020-12) Bashar, Md. Abul; Kabir, Eva Rahman; Haider, A.F.M Yusuf
Biosimilars are biological agents that are very similar to their reference product but follow a separate regulatory framework and marketing strategy and usually include interferons, interleukins, growth factors, hormones and monoclonal antibodies. The implementation of biologics as targeted treatment strategy, significantly improved health condition of patients with rheumatoid arthritis compared to other conventional therapies. In this study, the biosimilars that can be used in the management of rheumatoid arthritis have been highlighted and an insight on its importance in terms of patient accessibility and affordability provided. The treatment algorithm of biosimilars and the guidelines followed for it to be prescribed to such patients have also been mentioned in this study. Moreover, the role of molecular docking and drug repurposing in discovering biosimilars and minimizing the development task of a lead molecule considering the growing demand for these biological agents worldwide have been discussed in this study.
COLD TOLERANT MECHANISM OF SOME SELECTED RICE SEEDLINGS AT LOW TEMPERATURE ENVIRONMENT
(HAJEE MOHAMMOD DANESH SCIENCE AND TECHNOLOGY UNIVERSITY, DINAJPUR, 2012-12) Bashar, Md. Abul; Professor Dr. Bikash Chandra Sarker
A field experiment was carried out to investigate the physio-morphological characteristics of seedlings four rice cultivars for screening cold survival during low temperature in Northwest of Bangladesh. The test rice cultivars were V1, NERICA-10; V2, IR- 40 (GSR-IRRI- 40); V3, Lafaya and V4, Gochi, respectively. The leaf proline, chlorophyll content, relative water content (RWC), protein, starch, seedling shoot length, shoot weight and root length, root weight, total biomass, and seed germination rate were investigated. The V1 (NERICA-10) and V3 (Lafaya) seedling synthesized the higher leaf proline at low temperature than those of other tested cultivars. The highest chlorophyll-a and -b was in V1 (NERICA-10). The V3 cultivar (Lafaya) had the highest percentage of relative water content (92.93%). The V4 variety showed the highest content of protein percentage (13.35%). The highest percent starch content was found in V3 (29.82%). The V3 plants had the highest shoot weight at all times of experiment in 2012 irrespective of fresh and dried condition. This study infers that V1 (NERICA10) and V3 (Lafaya) varieties showed the better survival potentiality during cold temperature by over-synthesizing proline, chlorophyll and other physiomorphological parameters.
COLD TOLERANT MECHANISM OF SOME SELECTED RICE SEEDLINGS AT LOW TEMPERATURE ENVIRONMENT
(2012-12) Bashar, Md. Abul; Professor Dr. Bikash Chandra Sarker
A field experiment was carried out to investigate the physio-morphological characteristics of seedlings four rice cultivars for screening cold survival during low temperature in Northwest of Bangladesh. The test rice cultivars were V1, NERICA-10; V2, IR- 40 (GSR-IRRI- 40); V3, Lafaya and V4, Gochi, respectively. The leaf proline, chlorophyll content, relative water content (RWC), protein, starch, seedling shoot length, shoot weight and root length, root weight, total biomass, and seed germination rate were investigated. The V1 (NERICA-10) and V3 (Lafaya) seedling synthesized the higher leaf proline at low temperature than those of other tested cultivars. The highest chlorophyll-a and -b was in V1 (NERICA-10). The V3 cultivar (Lafaya) had the highest percentage of relative water content (92.93%). The V4 variety showed the highest content of protein percentage (13.35%). The highest percent starch content was found in V3 (29.82%). The V3 plants had the highest shoot weight at all times of experiment in 2012 irrespective of fresh and dried condition. This study infers that V1 (NERICA10) and V3 (Lafaya) varieties showed the better survival potentiality during cold temperature by over-synthesizing proline, chlorophyll and other physiomorphological parameters.
Discover the Impact of Sulfur and Potassium on the Nitrogen, Phosphorus, Sulfur and Potassium Concentrations in Onion Bulbs
(Asian Journal of Research in Crop Science, 2024-12-29) Manik, Md. Mahmudul Hasan; Razzaque, Md. Abdur; Haque, Md. Imdadul; Bashar, Md. Abul; Joha, Md Ruhul Kuddus; Hossain, Alif
A scientific Research has been conducted using a RCBD technique with three replications, are focusing on two factors affecting onion growth. The purpose was to assess the impact of different sulfur levels S 1 = 5, S 2 =15, S 3 =25, and S 4 =35 kgha and potassium levels K 1 =100, K 2 =120, K 3 =140, and K 4 =160 kg /ha on the nutrient content of N, P, K, and S in onion bulbs was done in Sher-e-Bangla Agricultural University in Dhaka, Bangladesh. The time duration is October 2020 to June 2021. Based on the observations, it has been found that the bulb showed the highest level of nitrogen when treated with sulfur (5 kg/ha) and potassium (100 kg/ha respectively). In contrast, the lowest nitrogen level has been observed when the bulb was treated with sulfur and potassium (35 &140 kg/ha respectively). Furthermore, the bulb exhibited the highest concentrations of phosphorus (P), potassium (K), and sulfur (S) at a potassium 140 kg/ha and a sulfur 35 kg/ha. Conversely, the lowest values for these parameters were observed when the bulb was treated with the lowest amount of sulfur and potassium.
Stress-Deformation Characteristics of Selected Coastal Soils of Bangladesh and their Sampling Effects
(Bangladesh University of Engineering & Technology (BUET), Dhaka, Bangladesh, 2002-03) Bashar, Md. Abul; Safiullah, Prof. Dr. A.M.M.
A considerable development activity within the Coastal Region of Bangladesh has necessitated an understanding of the geotechnical behaviour of soils from this region. With this objective in view a study into strength-deformation, compressibility and intrinsic properties of reconstituted samples of Chittagong coastal soils were undertaken. This thesis presents stress-deformation characteristics of three selected coastal soils and their sampling effects. The soils were collected from Banskhali, Anwara and Chandanaish in Chittagong coastal belt of Bangladesh. The soils are low to medium plasticity (Liquid limit = 34 to 45 and Plasticity index = 10 to 20). Reconstituted samples of the three soils were prepared in the laboratory by K0- consolidation of slurry in a large cylindrical consolidation cell using a consolidation pressure of 150 kN/m2. Overconsolidated samples were prepared in the triaxial cell by releasing the maximum isotropic consolidation pressure of 150 kN/m2 to appropriate values to achieve overconsolidation ratios (OCR) of 1.5, 2, 5, 10, 20 and 30. The stress-deformation-strength, stiffness and pore pressure characteristics of reconstituted isotropically normally consolidated and overconsolidated "block" samples of the three coastal soils were investigated in the laboratory by performing undrained triaxial compression tests. Models for the prediction of undrained shear strength of normally consolidated and overconsolidated samples have been developed. To develop intrinsic models of compressibility, intrinsic compression lines (ICL) for the three soils under K0 and isotropic stress conditions have been established which can be used to determine compressibility indices of soils at any depth of known overburden pressure. State boundary surfaces (Roscoe and Hvorslev state boundary surfaces) and critical state lines of the three coastal soils have been established. The critical state parameters of the soils have also been evaluated. Constitutive models relating critical state soil parameters and plasticity index of the soils have been proposed. Applications of these models to undisturbed naturaj clays will require further investigation. The experimentally observed stress-strain behaviour of reconstituted normally consolidated samples of the three coastal soils have been compared with those predicted using two critical state models, namely, "Cam clay model" and "Modified Cam clay model". It has been found that the results predicted by using "Modified Cam clay model" compared more favourably with the observed experimental results than "Cam clay model" for the three coastal soils. The present study has also been carried out to investigate the effects of "perfect" sampling disturbance and tube sampling disturbances on engineering properties of reconstituted normally consolidated samples of the three coastal soils. Undrained triaxial compression tests were carried out on "in situ", "perfect" and "tube" samples. "In situ" samples were prepared by consolidating reconstituted specimens of 38 mm diameter by 76 mm high under K0-condition in the triaxial cell to its in situ stress state. "Perfect" samples were prepared from "in situ" samples by undrained release of the total stresses in the triaxial cell. "Tube" samples were prepared from the large diameter consolidated samples by inserting samplers of different area ratios, external diameter to thickness ratio (De/t) but of constant outside cutting edge angle (OCA) and internal diameter (Di). Area ratio, De/t ratio, OCA and Di of the samplers were 16.4% to 73.1%, 27.3 to 8.3, 5° and 38 mm, respectively. Undrained triaxial compression tests were carried out on reconsolidated "perfect" and "tube" samples of the three coastal soils to assess the suitability of various reconsolidation techniques to minimize sampling disturbance effects. Experimental results indicate that disturbances due to perfect and tube sampling have significant influence on the mechanical properties of coastal soils. The nature of the effective stress paths and por' pressure responses of both "perfect" and "tube" samples are markedly different from those of the "in situ" samples. The "perfect" and "tube" samples adopted stress paths and showed pore pressure responses which are more typical of overconsolidated clays. Disturbances due to perfect sampling led to reduction in the values of undrained shear strength (se), Skempton's pore pressure parameter A at peak deviator stress (Ap), initial tangent modulus (Ei) and secant stiffiess at half the peak deviator stress (E50) whilr axial strain at peak deviator stress (εp) increased due to total stress relief. Due to total stress relief, the reduction Su, Ei and E50 increased with the decrease of plasticity while the increase in c. increased with the decrease of plasticity of the soils. It is also evident that the decrease in mean effective stress (p') due to perfect sampling increases with decreasing plasticity of the soils. The initial effective stress (σ՛i) of "tube" samples reduced considerably because of disturbance caused by penetration of tubes. Compared with the "in situ" samples, values of s, E1, E50 and A of the "tube" samples decreased while sp increased. The changes in measured soil parameters between the "in situ" and "tube" san )les have been found to depend significantly on the sampler characteristics, i.e., area ratio, De/t ratio, used for retrieving the "tube" samples. The values of σ՛i, su, Ei and E50 were decreased due to increase in area ratio (or reduction in De/t ratio). The values of εp, however, increased due to increasing area ratio. A quantitative increase in the degree of disturbance (Dd) has been obtained due to increase in area ratio, while the values of Dd increased with the decrease of De/t ratio of sampler. Disturbance due to tube sampling has been found to depend on the plasticity of the samples of the three coastal soils. The highest reductions in a', st,. Ei and E 0 occurred in the least plastic samples, whereas the minimum reduction in σ՛i, su, Ei and E50 occurred in the most plastic samples. Among the samples of the coastal soils, the least plastic sample produced higher degree of disturbance than the most plastic sample.
Study of Present Scenario of Tidal Power Energy and Generation in Bangladesh
(Daffodil International University, 2022-03-30) Bashar, Md. Abul; Haque, Rukaiya
Tides are caused by the catching forces between the divine bodies of the Sun, Moon and Earth, which cause the sea waters to rise and fall. As technology advances, the utilization of electrical and electronic gadgets grows tremendously, necessitating the assembly of additional power to satisfy future demands. Tidal energy is one among the foremost promising renewable energy sources currently available. Tidal energy is non-polluting and renewable. due to these characteristics, it's unique and fitted to future use as an influence generating source. round the world, differing types of tidal power plants exist, each with a special tidal elovation. additionally, the mechanism of converting tidal energy into electricity varies by location. However, the method wants to capture energy from tides is usually just like that utilized in conventional hydroelectric power plants. The tides at several areas throughout the planet and along the Indian coast are going to be studied from the literature, as will tidally power plants across the planet, resources allocations for tidal power plants, and therefore the advantages and drawbacks of tidal power. Tidal energy is an old yet effective approach among them. Because tide is driven by the orbital mechanics of the systematic and are deemed limitless within a person's timeline, tidal power is considered a renewable energy source. Tidal power energy is additionally a pollution free source of energy of tons of promise. Tidal power might be a viable alternative to satisfy the present electricity shortage. Ocean wave and tidal power, with correct design, siting, deployment, operation, and maintenance, might be one among the foremost environmentally friendly electricity generation systems ever produced.
The Scenario of English Language Teaching in Bangladesh
(Daffodil International University, 2018-12-20) Bashar, Md. Abul
The purpose of the internship report was to find out “The Present Scenario of English Language Teaching in Bangladeshi school”. To accomplish this internship one need to find out a high school to observe and conduct class. In order to do this a recommendation letter was also provided by the university. Dhanmondi Government Boys’ High School was selected by the intern as a field to complete the project. Almost all of the information of the school was provided by class teachers and the facilitator. Teacher way of applying methods and techniques observed by the intern in three classes. In preparing the lesson, class teacher instruction was followed. Three classes were conducted to gather experience in which new methods and techniques were applied. The future course of action was developed by the teacher and student feedback. Altogether, the internship was done under a supervisor with honesty and sincerity.