Browsing by Author "Alqahtani, Mohammed S."

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Novel Benzothiazole Derivatives Synthesis and its Analysis as Diuretic Agents
(Hindawi Publications, 2023-04-12) Kemisetti, Durgaprasad; Amin, Ruhul; Alam, Faruk; Gacem, Amel; Emran, Talha Bin; Alsufyani, Taghreed; Alqahtani, Mohammed S.; Islam, Saiful; Matin, Mohammed Mahbubul; Jameel, Mohammed
Benzothiazoles, an anticonvulsant, antiviral, antihypertensive, and cancer-fighting medication of the heterocyclic scaffold family, also acts as antibacterial and antiviral agents. There is much interest in this chemical’s production because of the strong and vital biological action it possesses. Substituted aromatic aldehydes were combined with 2-amino-benzothiazole-6-sulfonic acid amides, or Schiff base derivatives, to create Schiff base derivatives. Recrystallized, characterized, and tested for diuretic efficacy in vivo using online tools, m.p. (melting point), Rf, FTIR (Fourier transform infrared), 1H-NMR (proton nuclear magnetic resonance) data The molecular characteristics of all the substances created were estimated using Lipinski’s rule of 5, OSIRIS (software) molecular property explorer, Molsoft, and Autodock 4.0 docking software. Male Wistar rats were used to make all the compounds traditionally in order to test for diuretic activity. Neither the elemental nor the spectral information for the synthesized compounds disagreed. There were five different methods used to evaluate these compounds: Lipinski rule of five, Molsoft to determine molecular characteristics, PASS (prediction of activity spectra for substances) values to determine the diuretic effect, and OSIRIS software to determine toxicology. In order to investigate the diuretic effects of the selected drugs, docking analysis was used. Acetazolamide was shown to have a diuretic effect that was superior to that of compounds IIIb and IIIe, whereas 2-{(E)-[(3-hydroxyphenyl)methylidene]amino}-1,3-benzothiazole-6-sulfonamide (IIIb) was found to be the most promising potential.
Physical, Structural, Elastic and Optical Investigations on Dy3+ Ions Doped Boro-Tellurite Glasses for Radiation Attenuation Application
(Elsevier, 2023-05-15) Bassam, S.A.; Naseer, K.A.; Keerthana, V.K.; Teresa, Evangelin; Sangeeth, C.S. Suchand; Mahmoud, K.A.; Sayyed, M.I.; Alqahtani, Mohammed S.; Shiekh, E. El; Khandaker, Mayeen Uddin
A set of Dy3+ ions doped boro-tellurite glasses is prepared using the melt quenching method and its radiation resisting aptitude is estimated through various structural and elastic features. The results were interpreted due to the effect of TeO2 concentration in the glass systems. The observed molar volume (Vm) values reduced with the rise in the tellurium content with the creation of more bridging oxygens in the structure. The cross-link density rises the rigidity of the glass and its density. Additionally, boron-boron separation and tellurium-tellurium separation, and optical band gap were computed to prove the connectivity of the system which is noted to reduce with the rise in the tellurium content. Glass with 40% TeO2 is observed to hold high elastic moduli and consequently high density and connectivity which are vital requirements for effective radiation shielding. Moreover, the Monte Carlo N-Particle transport code version 5 is used to qualify the γ-ray shielding properties. The qualification of the shielding properties showed that the linear attenuation coefficient was enhanced by a factor of 80% from 0.248 cm−1 to 0.358 cm−1 by raising the TeO2 concentration between 0 and 40 wt %, respectively. The enhancement on linear attenuation coefficient was reflected on the half value thickness (Δ0.5, cm) and thickness equivalent (Δeq, cm) of the fabricated samples where Δ0.5 and Δeq values reduced with raising the TeO2 concentration between 0 and 40 wt %.
Radiation Doses Assessment and Radon Exhalation Rate from the Soils of Albyda Area, Yemen
(Elsevier, 2024-10-07) Hanfi, Mohamed Y.; El-Gamal, Hany; Hussien, Maher Taher; Khandake, Mayeen Uddin; Alqahtani, Mohammed S.; Hasabelnaby, Mohamed
This work focuses on evaluating the potential health hazards posed by natural radionuclides in soil samples collected from 20 different sites in the Albyda area, Yemen. The activity concentrations of 226Ra, 232Th and 40K and radon exhalation rates in the soil samples were investigated. Alpha GUARD detector was used to estimate 222Rn concentration, while activity levels for natural radionuclides were measured by HPGe detector. The average values obtained for 226Ra, 232Th, and 40K were 27.60 ± 2.40 Bq/kg, 35.07 ± 2.45 Bq/kg, and 544.71 ± 48 Bq/kg, respectively, and for 222Rn concentrations were 135 ± 15 Bq/m3. Our findings show that the concentrations of radionuclides were within the limits of the world average established by UNSCEAR, except the concentrations of 40K, which was slightly higher than the world average (420 Bq/kg), while the average 222Rn concentration was lower than the ICRP reference level of 300 Bq/m3, and the average area exhalation rate 3.46 × 10−5 Bq m−2 s−1 was lower than the UNSCEAR world average of 0.016 Bq m−2 s−1. Therefore, the soil in this study does not pose any radiological hazard to the population due to the harmful effects of ionizing radiation. The results of the current study highlight the potential health hazard posed by radon and radioactivity levels in the soil samples from Albyda area, Yemen, which will help to increase awareness of the radiological hazard and the data could also be used as a reference for future research on radioactivity mapping in the study area.
Risk assessment and rare metals mineralization associated with alteration aspects of Rhyolite flow tuffs, Egypt
(Scopus, 2024-02) Hanfi, Mohamed Y.; Gawad, Ahmed E. Abdel; Donia, Atef M. Abu-; Khoziem, Hanaa A. Abu; Mira, Hamed I.; Khandaker, Mayeen Uddin; Alqahtani, Mohammed S.; Elshoukrofy, A. .Sh..M.
Argillic alteration and hematitization are the two extensive alterations that affected Um Safi rhyolite flow tuffs. Rare metal mineralization including radioactive minerals (thorite, uranothorite), Nb-bearing minerals (columbite, yettrocolumbite, Nb-rutile), zircon, REE-minerals (LREE-carbonate, xenotime) as well as molybdite, pyrite, fluorite, hematite and ilmenite have been identified by using Energy Dispersive Spectrometer (EDS) and are well recorded in argillic and hematitized samples. The investigated rhyolite flow tuffs show that the activity concentration of radionuclides changed from 1.2 to 453.2 Bq kg−1 for 238U, from 3.2 to 489.6 Bq kg−1 for 232Th, and from 31.3 to 88954.6 Bq kg−1 for 40K. The mean values of 238U, 232Th, and 40K activity concentrations are 90.8 ± 84.5, 122.9 ± 90.5 and 6286.7 ± 1562.2 Bq kg−1, respectively. The hazard factors are estimated. Their results exceeded the recommended limit. Thus, the investigated rhyolite flow tuffs are not safe to use in building materials and other construction industries. A multi-statistical approach is performed to show the correlation between the radioactive concentration and radiological hazard factors. This approach illustrates the positive correlation between uranium and thorium due to their contribution from the natural radioactive series—moreover, a strong correlation was obtained between potassium and all radiological parameters. Thus, the radioactive hazards impact in the present study is related to the presence of radioactive minerals such as thorite and uranothorite in addition to other accessory minerals.
Risk Assessment and Rare Metals Mineralization Associated with Alteration Aspects of Rhyolite Flow Tuffs, Egypt
(Elsevier, 2024-02-15) Hanfi, Mohamed Y.; Gawad, Ahmed E. Abdel; Gawad, Abdel; Abu-Donia, Atef M.; Khoziem, Hanaa A. Abu; Mira, Hamed I.; Khandaker, Mayeen Uddin; Alqahtani, Mohammed S.; Elshoukrofy, A.Sh.M.
Argillic alteration and hematitization are the two extensive alterations that affected Um Safi rhyolite flow tuffs. Rare metal mineralization including radioactive minerals (thorite, uranothorite), Nb-bearing minerals (columbite, yettrocolumbite, Nb-rutile), zircon, REE-minerals (LREE-carbonate, xenotime) as well as molybdite, pyrite, fluorite, hematite and ilmenite have been identified by using Energy Dispersive Spectrometer (EDS) and are well recorded in argillic and hematitized samples. The investigated rhyolite flow tuffs show that the activity concentration of radionuclides changed from 1.2 to 453.2 Bq kg−1 for 238U, from 3.2 to 489.6 Bq kg−1 for 232Th, and from 31.3 to 88954.6 Bq kg−1 for 40K. The mean values of 238U, 232Th, and 40K activity concentrations are 90.8 ± 84.5, 122.9 ± 90.5 and 6286.7 ± 1562.2 Bq kg−1, respectively. The hazard factors are estimated. Their results exceeded the recommended limit. Thus, the investigated rhyolite flow tuffs are not safe to use in building materials and other construction industries. A multi-statistical approach is performed to show the correlation between the radioactive concentration and radiological hazard factors. This approach illustrates the positive correlation between uranium and thorium due to their contribution from the natural radioactive series—moreover, a strong correlation was obtained between potassium and all radiological parameters. Thus, the radioactive hazards impact in the present study is related to the presence of radioactive minerals such as thorite and uranothorite in addition to other accessory minerals.