Browsing by Author "Akhtar, Muhammad Furqan"

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Multifaceted Role of Natural Sources for COVID-19 Pandemic As Marine Drugs
(Daffodil International University, 2022-05-26) Rahman, Md. Mominur; Islam, Md. Rezaul; Shohag, Sheikh; Hossain, Md. Emon; Shah, Muddaser; shuvo, Shakil khan; Khan, Hosneara; Chowdhury, Md. Arifur Rahman; Bulbul, Israt Jahan; Hossain, Md. Sarowar; Sultana, Sharifa; Ahmed, Muniruddin; Akhtar, Muhammad Furqan; Saleem, Ammara; Rahman, Md. Habibur
COVID-19, which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly spread over the world, posing a global health concern. The ongoing epidemic has necessitated the development of novel drugs and potential therapies for patients infected with SARS-CoV-2. Advances in vaccination and medication development, no preventative vaccinations, or viable therapeutics against SARS-CoV-2 infection have been developed to date. As a result, additional research is needed in order to find a long-term solution to this devastating condition. Clinical studies are being conducted to determine the efficacy of bioactive compounds retrieved or synthesized from marine species starting material. The present study focuses on the anti-SARS-CoV-2 potential of marine-derived phytochemicals, which has been investigated utilizing in in silico, in vitro, and in vivo models to determine their effectiveness. Marine-derived biologically active substances, such as flavonoids, tannins, alkaloids, terpenoids, peptides, lectins, polysaccharides, and lipids, can affect SARS-CoV-2 during the viral particle’s penetration and entry into the cell, replication of the viral nucleic acid, and virion release from the cell; they can also act on the host’s cellular targets. COVID-19 has been proven to be resistant to several contaminants produced from marine resources. This paper gives an overview and summary of the various marine resources as marine drugs and their potential for treating SARS-CoV-2. We discussed at numerous natural compounds as marine drugs generated from natural sources for treating COVID-19 and controlling the current pandemic scenario.
Resveratrol and Neuroprotection
(Daffodil International University, 2022-05-12) Islam, Fahadul; Nafady, Mohamed H.; Islam, Md. Rezaul; Saha, Susmita; Rashid, Salma; Akter, Aklima; Rashid, Md. Harun‑ Or‑; Akhtar, Muhammad Furqan; Perveen, Asma; Ashraf, Ghulam Md.; Rahman, Md. Habibur; Sweilam, Sherouk Hussein
Alzheimer’s disease (AD) is the most common cause of dementia and cognitive impairment; yet, there is currently no treatment. A buildup of Aβ, tau protein phosphorylation, oxidative stress, and inflammation in AD is pathogenic. The accumulation of amyloid-beta (Aβ) peptides in these neurocognitive areas is a significant characteristic of the disease. Therefore, inhibiting Aβ peptide aggregation has been proposed as the critical therapeutic approach for AD treatment. Resveratrol has been demonstrated in multiple studies to have a neuroprotective, anti-inflammatory, and antioxidant characteristic and the ability to minimize Aβ peptides aggregation and toxicity in the hippocampus of Alzheimer’s patients, stimulating neurogenesis and inhibiting hippocampal degeneration. Furthermore, resveratrol’s antioxidant effect promotes neuronal development by activating the silent information regulator-1 (SIRT1), which can protect against the detrimental effects of oxidative stress. Resveratrol-induced SIRT1 activation is becoming more crucial in developing novel therapeutic options for AD and other diseases that have neurodegenerative characteristics. This review highlighted a better knowledge of resveratrol’s mechanism of action and its promising therapeutic efficacy in treating AD. We also highlighted
Retraction Note: Multifaceted Role of Natural Sources for Covid-19 Pandemic as Marine Drugs (Environmental Science and Pollution Research, (2022), 29, 31, (46527-46550), 10.1007/S11356-022-20328-5)
(Springer Nature, 2024-03-14) Rahman, Md. Mominur; Shohag, Sheikh; Hossain, Md. Emon; Shah, Muddaser; Khuvo, Shakil Khan; Khan, Hosneara; Chowdhury, Md. Arifur Rahman; Bulbul, Israt Jahan; Hossain, Md. Sarowar; Sultana, Sharifa; Ahmed, Muniruddin; Akhtar, Muhammad Furqan; Saleem, Ammara; Rahman, Md. Habibur
COVID-19, which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly spread over the world, posing a global health concern. The ongoing epidemic has necessitated the development of novel drugs and potential therapies for patients infected with SARS-CoV-2. Advances in vaccination and medication development, no preventative vaccinations, or viable therapeutics against SARS-CoV-2 infection have been developed to date. As a result, additional research is needed in order to find a long-term solution to this devastating condition. Clinical studies are being conducted to determine the efficacy of bioactive compounds retrieved or synthesized from marine species starting material. The present study focuses on the anti-SARS-CoV-2 potential of marine-derived phytochemicals, which has been investigated utilizing in in silico, in vitro, and in vivo models to determine their effectiveness. Marine-derived biologically active substances, such as flavonoids, tannins, alkaloids, terpenoids, peptides, lectins, polysaccharides, and lipids, can affect SARS-CoV-2 during the viral particle’s penetration and entry into the cell, replication of the viral nucleic acid, and virion release from the cell; they can also act on the host’s cellular targets. COVID-19 has been proven to be resistant to several contaminants produced from marine resources. This paper gives an overview and summary of the various marine resources as marine drugs and their potential for treating SARS-CoV-2. We discussed at numerous natural compounds as marine drugs generated from natural sources for treating COVID-19 and controlling the current pandemic scenario.